Depakote and Suicidal Ideation

If you haven’t already heard — research suggests a link between Depakote and an increase in suicidal ideation. This may be in the form of frequent thoughts about death, wanting to die, planning suicide, or active suicide. It is not clear yet why Depakote would have this effect.

Personally, I have taken Depakote steadily for 12 years (well, except when I stopped my meds ) and I have not noticed any increase in suicidal ideation, either on regular doses or when my dosage was raised. I think the increase is more likely when you first start on Depakote, or when the dose is titrated upward. Doctors and patients should be especially alert at these times for any signs of trouble.